Stampin' Up! sells these MDF blocks that make a fun home decor item. I made one of the sides into word art, using my Big Shot Bigz alphabet dies – Serif Essentials. I stamped images randomly onto cardstock, cut that into 3" x 3" squares and then used Real Red cardstock to create the letters. The other sides feature photos – some I used 3" x 3" sized photos, and I used some 6" x 6" photos that I cut into 3" x 3" squares to make a puzzle.
To adhere the cardstock or photos, you could use Tombow Adhesive or a decoupage kind of glue.
I'm planning on offering a class featuring the blocks in the near future – email me if you want to be sure to hear about it!